基于近似计算技术的FPRM电路面积优化

近似计算技术通过降低电路输出精度实现电路功耗、面积、速度等方面的优化.本文针对RM（Reed-Muller）逻辑中"异或"运算特点，提出了基于近似计算技术的适合FPRM逻辑的电路面积优化算法，包括基于不相交运算的RM逻辑错误率计算方法，及在错误率约束下，有利于面积优化的近似FPRM函数搜索方法等.优化算法用MCNC（Microelectronics Center of North Carolina）电路进行测试.实验结果表明，提出的算法可以处理输入变量个数为199个的大电路，在平均错误率为5.7%下，平均电路面积减少62.0%，并在实现面积优化的同时有利于实现电路的动态功耗的优化且对电路时延影响不大.     

基于时间延迟的多类型维修与经济生产批量联合优化研究

针对目前未能较好的综合考虑多维修类型与经济生产批量联合优化的问题，首先考虑多类型维修关系，基于时间延迟理论求出故障和缺陷次数的表达式；其次，在此基础上，综合考虑生产费用和维修费用的基础上，构建了多类型维修和经济生产批量联合优化模型，以单位时间内总费用最小为优化目标，获得最优检查间隔期和经济生产批量；最后，通过算例分析验证了模型的有效性，说明了第一类缺陷检查次数的多少对费用和经济生产批量影响不大。     

Formulation,optimization, hemocompatibility and pharmacokinetic evaluation of PLGA nanoparticles containing paclitaxel

Objective: Paclitaxel (PTX)-loaded polymer (Poly(lactic-co-glycolic acid), PLGA)-based nanoformulation was developed with the objective of formulating cremophor EL-free nanoformulation intended for intravenous use.

Significance: The polymeric PTX nanoparticles free from the cremophor EL will help in eliminating the shortcomings of the existing delivery system as cremophor EL causes serious allergic reactions to the subjects after intravenous use.

Methods and results: Paclitaxel-loaded nanoparticles were formulated by nanoprecipitation method. The diminutive nanoparticles (143.2?nm) with uniform size throughout (polydispersity index, 0.115) and high entrapment efficiency (95.34%) were obtained by employing the Box–Behnken design for the optimization of the formulation with the aid of desirability approach-based numerical optimization technique. Optimized levels for each factor viz. polymer concentration (X1), amount of organic solvent (X2), and surfactant concentration (X3) were 0.23%, 5?ml %, and 1.13%, respectively. The results of the hemocompatibility studies confirmed the safety of PLGA-based nanoparticles for intravenous administration. Pharmacokinetic evaluations confirmed the longer retention of PTX in systemic circulation.

Conclusion: In a nutshell, the developed polymeric nanoparticle formulation of PTX precludes the inadequacy of existing PTX formulation and can be considered as superior alternative carrier system of the same.     

增强现实场景下移动边缘计算资源分配优化方法

针对高速数据传输及计算所带来时延和终端设备能耗问题，提出了一种在上行链路采用等功率分配的传输方案。首先，依据增强现实（AR）业务的协作属性建立了针对AR特性的系统模型；其次，详细分析了系统帧结构，建立以最小化系统消耗总能量为优化目标的约束条件；最后，在保障延迟和功耗满足约束的条件下，建立了基于凸优化的移动边缘计算（MEC）资源优化求解数学模型，从而获得最优的通信和计算资源分配方案。与独立传输相比，该方案在最大延迟时间分别为0.1 s和0.15 s时的总能耗降幅均为14.6%。仿真结果表明，在相同条件下，与基于用户独立传输的优化方案相比，考虑用户间协作传输的等功率MEC优化方案能显著减少系统消耗的总能量。     

Optimization of Process Conditions for Styrene Epoxidation Based on the Artificial Intelligence Method

A novel prediction and optimization method based on improved generalized regression neural network (GRNN) and particle swarm optimization (PSO) algorithm is proposed to optimize the process conditions for styrene epoxidation to achieve higher yields. This model was designed to optimize the five input parameters reaction temperature and time as well as catalyst, solvent, and oxidant dosage. The output of the improved GRNN was given to the PSO algorithm to optimize the process conditions. The optimal smoothing parameter σ of GRNN was chosen from the training sample with a minimum cross validation error. Under the five optimized process conditions the maximum yield reached 95.76 %. This innovative model of improved GRNN hybrid PSO algorithm proved to be a useful tool for optimization of process conditions for styrene epoxidation.     

基于改进飞蛾扑火优化算法的MIMO雷达相位编码信号集设计

提出一种MIMO雷达相位编码信号集设计方法，该方法对飞蛾扑火优化算法进行改进，利用改进的飞蛾扑火算法优化相位编码信号集，提高其正交性.在改进方法中，增加对火焰的更新过程，使火焰不仅能够保存最优飞蛾位置还具有搜索最优解的功能.优化过程以自相关函数旁瓣峰值和、互相关函数峰值和，以及自相关函数旁瓣能量、互相关函数能量作为算法适应度函数.仿真实验结果表明，改进方法明显提高了飞蛾扑火优化算法的收敛速度和收敛精度，且优化得到的信号集具有较低的自相关旁瓣值和互相关值.     

医院级CT辐射剂量及诊断剂量水平研究

探讨医院级各部位CT扫描辐射剂量及成人CT检查诊断剂量水平。采集2018年2月—2019年1月本院在GE Light Speed 16 CT设备上进行诊断性CT检查的全部成年人共15 440例的CT检查数据,按照检查部位进行分类,统计各部位的容积剂量指数(CTDI_vol)、剂量长度乘积(DLP)。使用SPSS 19统计软件分析CTDI_vol、DLP的四分位数并计算有效剂量(ED)。结果表明,各部位CTDI_vol的诊断剂量参考水平(DRL)值为:颅脑87.75 mGy、肺部8.09 mGy、上下腹15.82 mGy、上下腹盆腔15.79 mGy;各部位DLP的诊断剂量参考水平(DRL)值为:颅脑1 053.03 mGy·cm、肺部245.19 mGy·cm、上下腹269.96 mGy·cm、上下腹盆腔835.20 mGy·cm。研究中发现肺部CTDI_vol、DLP的DRL值(分别为8.09 mGy、245.19 mGy·cm)低于我国其他地区和其他国家的DRL值;60岁以下患者肺部CT检查CTDI_vol、DLP的DRL值低于8.09 mGy、245.19 mGy·cm,60岁以上患者肺部CT检查CTDI_vol、DLP的DRL值高于8.09 mGy、245.19 mGy·cm。通过研究可以确定医院级各部位CT检查辐射剂量及成人CT检查诊断剂量水平,能为优化CT检查扫描技术和监测辐射剂量提供基础。     

An enhanced data-driven polynomial chaos method for uncertainty propagation

As a novel type of polynomial chaos expansion (PCE), the data-driven PCE (DD-PCE) approach has been developed to have a wide range of potential applications for uncertainty propagation. While the research on DD-PCE is still ongoing, its merits compared with the existing PCE approaches have yet to be understood and explored, and its limitations also need to be addressed. In this article, the Galerkin projection technique in conjunction with the moment-matching equations is employed in DD-PCE for higher-dimensional uncertainty propagation. The enhanced DD-PCE method is then compared with current PCE methods to fully investigate its relative merits through four numerical examples considering different cases of information for random inputs. It is found that the proposed method could improve the accuracy, or in some cases leads to comparable results, demonstrating its effectiveness and advantages. Its application in dealing with a Mars entry trajectory optimization problem further verifies its effectiveness.